Andrew Huberman explained in 2021, on the Power Project podcast, that he had never touched exogenous testosterone until then, at age 45.
However, as part of research for a book he’s writing (which covers hormone optimization), he wanted to experiment and experience firsthand what it’s like.
In this post, we’ll look at the TRT regimen he described using.
Andrew’s TRT Regimen
- In the clip above (source) Andrew explains that, under doctor’s supervision, he began by taking a “typical TRT dosage” of 160 mg per week of testosterone cypionate. Split into 2 weekly doses (.4 ml and .3ml – using a 200 mg per ml syringe).
- Now, it’s worth caveating that the maths on that sounds off (.7ml (.4 + .3) of a 200 mg/ml syringe is 140 mg), so it’s possible he mis-spoke and meant 140 mg – but you can hear in the clip above he definitely says 160 mg.
He found it gave him a ton of energy, but with unwanted side effects, specifically:
- Trouble sleeping
- A small amount of anxiety
As more time elapsed following the injection, the negative side effects gradually subsided, but they would reemerge each time he administered another dose, resetting the cycle.
^ Testosterone cypionate, which is used for TRT
So, instead of stopping completely, he cut the dose right down to:
- 20 mg every 3 days (which is .1 ml in the 200 mg/ml syringe)
He says he feels really good on this dose. His total testosterone went from 800 to 1400 ng/dl, and his blood lipids improved.
Note: In 2026 he posted on X about taking 20 mg EOD (every other day), rather than every 3 days, as above. Presumably switching to that cadence after the above.
While he’s experimenting with the TRT he came off the Tongkat Ali & Fadogia Agrestis combination. Presumably, so that he can see how the TRT affects him on its own, without supplements that also work directly on his hormones.
Aromatase Inhibitor?
^ Clip from YouTube interview of Andrew discussing Anastrozole
Aromatase inhibitors, if you’re not already familiar, are drugs that block the conversion of Androgens (such as testosterone) into estrogens. That process is normally called ‘aromatization’ – so drugs that block the process are named aromatase inhibitors.
Andrew explains that he experimented with an aromatase inhibitor called anastrozole – which he got re-compounded down to a very low dose of .1 mg, which he describes as a ‘minuscule amount’.
Unfortunately he ran into a few issues taking it:
- He didn’t feel great on it
- His memory felt slightly off
- His achilles heel suddenly started hurting when jogging, which then immediately resolved itself when he stopped taking it
Therefore he decided against taking an aromatase inhibitor.
^ An example brand of Anastrazole – note that at 1mg per tablet, it’s 10x the dose Andrew tried
Noticeable Effects from TRT
So how does Andrew feel on this low dose of testosterone every 3 days…
- He notes that the extra testosterone gives him more energy, but calm energy (perhaps as opposed to when taking stimulants).
- He lost all cravings for sweet foods but instead has strong cravings for meat, egg yolks and fat.
Huberman’s TRT Tips
In the same podcast, Andrew mentions a few tips for people interested in TRT.
- Firstly, ideally, get your total testosterone, free testosterone and other hormone levels checked whilst you’re young and healthy. For example, if you know what your levels were when you were 25 and brimming with energy, then later you can try to re-emulate that with TRT.
- This is particularly important because everyone is slightly different – so a one-size-fits-all target for hormones does not work.
- Similar to the Tongkat Ali & Fadogia Agrestis supplementation, you want to make sure you’ve got all the low-hanging fruit optimized first. Namely:
- Good quality sleep
- Healthy diet
- Regular exercise (but not overtrained)
- Avoiding chronic stress
- It’s possible that just by optimizing those things, you’ll see a noticeable improvement in your hormone and energy levels.
- Andrew tested his hormone levels prior to starting on TRT, and then 4 weeks later after commencing, to make it wasn’t having a negative impact.
^ Clip from YouTube interview of Andrew discussing steps to take prior to TRT
Prior Testosterone Support?
Prior to this experiment, Huberman discussed using the following supplements in the context of boosting testosterone:
| Supplement | Dose / Notes |
|---|---|
| Tongkat Ali | 400 mg daily |
| Fadogia Agrestis | 400 – 600 mg daily, cycled |
| Zinc | Important for maintaining healthy testosterone levels |
| Boron | 2 – 4 mg per day |
Huberman said that prior to taking these, his total testosterone was at around 600.
After he started taking Tongkat Ali and Fadogia Agrestis, it went up approximately 200 points to the high 700s / low 800s (ng/dL).
He continued taking these supplements consistently for several years.
Roundup
Whilst the above covers Andrew’s usage of TRT in 2021, I’m not aware of up to date information on what he’s doing currently.
He may be doing the same cycle, something different, or he may have stopped completely.
If you’ve any questions, please leave them below in the comments.
Further Learning
- To learn more about testosterone & strength, see his YouTube videos on the subject:
Disclaimer: The above information is for research and educational purposes only and not a substitute for professional medical advice. See full medical disclaimer.
Note: We have no affiliation with Andrew Huberman - this article is based on publicly shared information.
