Joe Rogan TRT Protocol Explained

Whilst we don’t know every detail of Joe Rogan’s TRT protocol, here’s what we do know…

Rogan says he started testosterone replacement therapy (TRT) at age 37/38, originally using testosterone creams, which weren’t very effective.
Then at 39 he progressed to weekly injections, under the close supervision of his doctor.
During his 2021 podcast, he mentioned he now injects testosterone every 3 days, using an insulin needle, which is smaller than the needle doctors typically suggest. This 3-day approach more closely resembles our natural testosterone cycles, compared to injecting once per week, which is often suggested.
In a separate 2021 podcast, he also mentions taking 1 IU (0.33 mg) of human growth hormone (hGH) per day. He mentions it at 6m 20s of this video.

This approach helps to replicate hormone levels he would have experienced in his late 20s.

*Younger vs Older Joe Rogan – Less hair, more tattoos, similar physique*

Table of Contents

Rogan Further Explains His Use of TRT

Rogan explains:

“Testosterone replacement therapy, there’s a real science to it.

The idea is you don’t take too much, you take what you would have in your body if you were a younger man.

People are like well you’re not a younger man anymore well, duh, like, people just want you to wither away and die.”

^ Short video clip of Rogan talking about his use of TRT

In the next clip, Rogan goes on to say:

Quote:
“All that matters is that you have testosterone in your system. If you don’t have it in your system, you’re not going to feel as good.

It’s real simple, if you’re fine, with not feeling as good – good! If you’re not fine with it, this is 2018, hormone replacement exists for a reason – and that reason is that it makes you feel way better, it makes your body work way better.

You can avoid a host of ailments and conditions related to your body breaking down due to age with hormone replacement therapy. The key to doing it though is to do it correctly. You’re supposed to go to a doctor who is going to test your blood levels, test your nutrient levels, and adjust your diet first.

The first thing that happens, they want to find out:

How much you’re sleeping
How stressed out you are
How much water you’re drinking
Are you getting the proper amount of protein – are you eating correctly?

Then they want to get you off the:

Sugar
Alcohol
Cigarettes

Before you do anything.

This is a multi-month process that I went through. They get you off of all these different things first.

Then they start adding testosterone. It takes a bit of time to figure out what works best. And then you get to a point where you have the hormone levels of a healthy young man. You don’t want to elevate, you don’t want to be higher than that. That’s where you get problems.

There are ways of elevating your hormones naturally, they just don’t work as well. Whether it’s deadlifts, or running hills, doing sprints, they work a little bit better than nothing. But there’s going to be a difference.”
/Quote

^ Short video clip of Rogan discussing how he got started and why he uses TRT

So as you can see – Rogan’s a big fan of hormone replacement therapy.

It seems to be fairly undisputed in the medical community that testosterone decreases with age. One study¹ suggests “free testosterone”² (the metabolically active testosterone not bound up with SHBG or albumin) decreases by 2% per year from the age of 40. The study notes that poor health may accelerate the age-related decline in hormone levels. So the healthier we can keep our bodies, the slower the decline may be.

Traditionally, testosterone replacement therapy has been thought of as something only a small percentage of the population need, if they have chronically low levels of testosterone.

Rather than seeing the age-related decline as something to be fixed. Now, gradually, it’s become more mainstream, as a method for those who can afford it to improve their quality of life as they age.

It’s not something to be taken lightly however, and you certainly don’t want to take testosterone if you don’t need it.

As Rogan has done, the therapy needs to be taken under the guidance and supervision of a doctor who specializes in hormone replacement therapy – with regular blood tests and check ups. They will be best positioned to discuss the complexities of the treatment, and whether or not it’s something that would be safe and beneficial to take.

Supplements That May Help Support Testosterone (Beyond TRT)

While this article centers on the TRT approach linked to Joe Rogan, some prefer supplements to support natural testosterone. Andrew Huberman has discussed several options that may help when combined with solid lifestyle habits.

Supplement	Dose / Notes
Tongkat Ali	400 mg daily
Fadogia Agrestis	400 – 600 mg daily, cycled
Zinc	Important for maintaining healthy testosterone levels
Boron	2 – 4 mg per day

Tongkat Ali

Tongkat Ali is a Southeast Asian herbal extract often mentioned by Andrew Huberman as a way to support natural testosterone, an alternative to the TRT approach associated with Joe Rogan.

A typical dose is 400 mg daily, ideally taken early in the day. Consistent use is generally recommended, and cycling isn’t usually necessary unless bloodwork suggests otherwise.

Examples of common brands include:

Product	Price per 400 mg	Discount Code
Momentous – Tongkat Ali	$0.66	(see 20-35% off Momentous discount)
Solaray – Tongkat Ali	$0.25	(see 20% off iHerb coupon)
Swanson – Tongkat Ali	$0.12	(see 20% off iHerb coupon)

Fadogia Agrestis

Fadogia Agrestis is another supplement Andrew Huberman has discussed for supporting testosterone by signaling the body to produce more naturally, rather than replacing it like the TRT approach linked to Joe Rogan.

He typically references a dose around 600 mg daily, often used in cycles (e.g., a couple of months on, followed by time off), alongside regular bloodwork.

Examples of brands include:

Nutricost – Fadogia Agrestis – 600 mg per capsule
EVLution – Fadogia Agrestis – 600 mg per capsule (see 20% off iHerb coupon))

Zinc

Zinc is essential for testosterone production, and Andrew Huberman notes that low levels can reduce it. It’s most useful for correcting deficiencies rather than boosting levels beyond baseline.

Typical intake is around 10–15 mg daily.

Examples of brands include:

Momentous – Zinc Picolinate – 15 mg per capsule (see 20-35% off Momentous discount)
Solgar – Zinc Picolinate – 22 mg per capsule (see 20% off iHerb coupon)

Boron

Boron is a trace mineral that Andrew Huberman has mentioned for supporting testosterone, potentially by increasing free testosterone levels.

He typically references 2–4 mg daily, which falls well within commonly suggested safe ranges.

Examples of brands include:

NOW – Boron – 3 mg per capsule (see 20% off iHerb coupon)
Source Naturals – Boron – 3 mg (complexed with 3 forms)

For a deeper dive into mechanisms, research, and dosing considerations, check out our Andrew Huberman Testosterone Supplement List article.

HGH – Human Growth Hormone

In addition to testosterone, Joe Rogan also takes growth hormone daily.

In episode #1580 with Andrew Schulz he mentions taking 1 IU per day (which is 0.33 mg).

Jump to 6m 20s of this video for where he mentions it.

Similar to testosterone, our body produces less growth hormone with age.

Who does Joe Rogan consult with for TRT?

Whilst I’m unsure if Rogan has explicitly stated who he works with for his hormone replacement therapy, he does seem to have a tight relationship with a Texas-based company called Ways 2 Well.

Their founder, Brigham Buhler, was on episode 1873, and I believe Rogan has separately mentioned using Ways 2 Well for stem cell injections – however I forget which episode he mentioned that.

If anyone knows more on this, please leave a comment.

References

1
Age Trends in the Level of Serum Testosterone and Other Hormones in Middle-Aged Men: Longitudinal Results from the Massachusetts Male Aging Study – Feldman et al (2002)
2
Free testosterone: clinical utility and important analytical aspects of measurement – Shea et al. (2014)

Disclaimer: The above information is for research and educational purposes only and not a substitute for professional medical advice. See full medical disclaimer.

Note: We have no affiliation with Joe Rogan - this article is based on publicly shared information.

Joe Rogan TRT Protocol Explained

Rogan Further Explains His Use of TRT