(This post is part of a longer post about Valter Longo’s fast mimicking diet. Also see this post for a breakdown of the FMD calories & macronutrients for each day, based off the below data)

Below is a list of the products contained within the Prolon FMD diet, including their total calories and macronutrient composition. The first image shows the distribution of each one across the 5 day:



Posted by Alex


  1. As I read the ingredients in the multiple vitamin I was concerned about the artificial ingredients:dl rather than d for E,folic acid rather than folate. In J. Fuhrman’s “Super Immunity” peer reviewed studies are cited indicating that while folate is quite beneficial, with regular folic acid consumption women are twice as likely to die of breast cancer and men are twice as likely to die ofin prostate cancer.


    1. Alex

      Hi David. Yes, was surprised too that it uses folic acid instead of folate. Whilst I don’t think short term use of folic acid will be an issue, I agree that in the long term folate seems to be more logical from a bioavailability standpoint – taking into account MTHFR mutations. When you say “dl rather than d for E” – what did you mean?


  2. Alex, thank you so much for your fantastic posts. One year in being diagnosed with an autoimmune disease I started water fasting 5 days and another 5 days, and saw a good reduction in symptoms. Since it became unsustainable for me I started doing the FMD instead. It helps, but I need to do two 5-day cycles per month to keep disease symptoms at bay. It puts me under financial strain and I need to find a different solution. I would thus prefer to compose the FMD myself. Yet I am a bit worried since I feel my inflammatory markers and the health of my organs depend on the success of this, so I want to follow the recommendations in the patent and the Cell Metabolism paper exaclty and in detail. If I exactly follow the protein/fat/carb ratios the Cell study listed, and add a simple multivitamin (+ 200mg DHA day 1 and day 5), would that imply I follow all the recommendations in the 2015 Cell Metabolism paper as well as Longo’s patent in detail? Or am I missing something? I was thinking of using the Cron-o-meter to calculate the ratios, or do you recommend using another app for this? Thank you so much!


    1. Alex

      Hi Leonie.

      That’s pretty awesome to hear that you’re finding success with 5-day fasting – what a god-send that must be.

      Agree, 2x boxes a month would become costly very quickly.

      What I would say, is that I *thought* it was as simple as keeping to the macros. But recently I heard Valter talking about how the composition of Prolon has been designed to get maximal benefit.

      For example, I thought the glycerol was to aid with hydration, but he was suggesting it’s more complicated than that.

      I’m going to butcher the rationale for adding glycerol (because I don’t fully understand it), but I think it’s something along the lines of – glycerol is produced by the body when fasting (naturally), and it then contributes to glucose production. Link to paper that explains more about glycerol & glucose production when fasting.

      So by adding exogenous glycerol (as Prolon does), we aid the body in producing glucose, which then acts as fuel while we’re not consuming anything.

      Suffice to say, it may be worth trying to emulate this in your DIY. One thought is that each Prolon day gives 118ml of “L-Drink”, and depending on how much you weigh (which defines how much of the bottle you use) you may have enough for 2 “doses”, so you could save the rest in the fridge and use it on your DIY FMD.

      Another possibility, is to actually buy your own vegetable glycerine, and add it yourself. The nutritional information on L-Drink says 29g carbs and 118Kcal per 100ml. According to MyFitnessPal 1g of glycerin is 1g carbs and 4Kcal. So per 100ml it’s about 29g of glycerine (if my maths is correct).

      The other thing the L-Drink has is potassium sorbate. I don’t know what the purpose of it is (if it’s just for extending the shelf life of L-Drink, or it has a potential fasting benefit also). And then it has flavouring, but that’s no biggie.

      The other thing I’d be wary of is including animal protein in your 5-day fast. Even if it conforms to the macros, I think it could be worth avoiding, because its amino acid profile is different to plant based proteins.

      Beyond what I’ve mentioned above + what you said in your post, that’s about my limit of knowledge in a DIY FMD.

      I believe Valter will publish more info in the future that gives us a greater window into the details of Prolon, so we can watch out for that. Hope that helps a bit.


      1. Thank you so much for your insightful response, Alex. That is very helpful! I am indeed incredibly grateful that I found a ‘method’ to push back disease symptoms. To be fair though: I do still have disease symptoms, but far less than I used to have prior to fasting. And of course I keep a careful eye on my diet when I’m not fasting too, and practice TRF (eating within a 4 hour time window every day). I also really have to fast 2 x 5 days or 10 days per month to keep disease symptoms at a minimum. Plus I am lowish in weight after these repeated cycles of fasting, and so I estimate overall I should practice around 20-25% calorie restriction (with optimal nutrition) which of course should help too with inflammation. It is quite challenging at moments, but yes: the change has been remarkable and I’m immensely grateful for that.
        I did exactly as you suggested the past period: first emptying the bottles of glycerol before opening a new one. So I should still have 35 days worth of glycerol that I could add to my self-made FMD’s. Thank you for your suggestion how to come up with a glycerine drink; this is very helpful too. I calculated all the macros you listed. But I did so per day, and in hindsight I assume I should do so for every single meal? It is not about eating 725 cal total per day of which 9% protein, but it is also important to restrict to 9% protein per meal I assume? Since otherwise one of my daily FMD-meals may have a higher protein content (compared to the others), which may negate some of the FMD-benefits?
        You are keeping up a fantastic blog here. Of course I have been very interested in the work of Dr. Patrick and Dr. Longo for years, and your posts are very interesting and useful. I will certainly keep reading here.


  3. What, specifically, do you eat/drink when you’re doing a FMD 5 day period?


    1. Alex

      Hi Tam. Just to clarify (so that I answer the right question). Are you asking what foods I eat when I do a 5 day FMD? And specifically, a DIY FMD, such that I’m not using the contents from the Prolon box?


  4. Thanks for your reply Alex. I use the published papers for the macronutrient mix so the protein will not exceed 9% on Day 1 to Day 5. Also for DIY FMD, I try to keep daily sugar intake below 30g. So far, it has typically been 7-10g for DIY FMD. Great info. you have on your website!


  5. Thanks, very useful information. But the calculated macro nutrients vary quite a bit from the published papers. Should we assume that the products’ nutrients mix are more precise for FMD?


    1. Alex

      Hi Jason, thanks for the message. Agree regarding the macro nutrients of the FMD box differing slightly from their published studies.

      That being said, I think the numbers are close enough for the information not to be conflicting.

      Yes, if you want to pick one to follow, it makes most sense to go with macros from the published studies.

      You’ll have probably read this already; but my summary was (copy and pasted):

      Whilst the calories/macronutrients differ slightly from the 2015 Cell Metabolism paper to the Prolon FMD box itself, there maintains an overall pattern.

      • Day 1 is always higher in nutritional value, at around 1,100 calories – with protein at 13% or lower.
      • Days 2-5 are always around 700 calories with protein kept below 15% of total nutrients.
      • Lastly, whilst the Prolon FMD diet has higher carbohydrate content than the Cell Metabolism paper used, it doesn’t go above 61% carbs.

      Keep those above key points in mind with your DIY FMD diet, and you won’t go far wrong.

      Perhaps key is to keep the protein content below 15%, that way you keep IGF-1 levels down; thought to be a core part of the fasting benefits.


Leave a reply

Your email address will not be published. Required fields are marked *