However, sometimes there’s a topic that doesn’t neatly into one of these posts. That’s where this post comes in – I’ll be using it to cover other topics that may be of interest.
(Dec 2021 – post under construction!)
Does Rhonda currently take it? No.
Rhonda’s current opinion on Rapamycin is that she’s interested in it, and eagerly awaiting results from the first human trials (see PEARL trial).
She notes that rapamycin increases the mean (and sometimes maximum) lifespan of a wide range of animal models. There hasn’t however been a lifespan or healthspan study in humans yet.
She mentions some of Rapamycin’s affects are:
- mTOR inhibition. With mTOR being a nutrient sensing enzyme in cells that modulates growth.
- It has immmune system modulating capability – it inhibits IL2 transcription – which blocks T-cell activation (this is key to its function in preventing organ rejection in transplant patients)
- It’s a strong anti-inflammatory
- It increases autophagy (via mTOR inhibition)
- It’s an NRF2 pathway activator
Rhonda then points to other ways to achieve some of these functions:
- She uses high doses of fish oils to decrease inflammation
- Sulforaphane is an NRF2 activator – which she takes – see post on sulforaphane
- Intermittent fasting can increase autophagy – which she practices.
^ This image illustrates how both mTOR complexes use nutrient status as inputs for their downstream actions – source